Seignalet Jean is a French surgeon who died in 2003, worked at a hospital in Montpellier. In the first part of his life, from 1969 to 1989 was director of the Laboratory of Immunology of Montpellier and obtained international fame for his work Histocompatibility. Since 1989, turned his attention to nutrition and immunology came to develop theories on the relationship between diet and the onset of various diseases.
He divided diseases into three main categories: autoimmune diseases, diseases of fouling / impregnation, disease elimination. Let's look in detail:
- Autoimmune diseases : autoimmunity is characterized by a cellular immune response and / or humoral immunity directed against various cell constituents of the organism. This response is aggressive and can cause injury or malfunction of various organs, resulting in clinical and biological anomalies that allow the diagnosis of autoimmune disease.
According to medical theory into force, to affirm the nature of autoimmune disease should have identified the autoantigen and autoantibody, and have proved that the disease can be transmitted by lymphocytes and / or by autoantibodies.
According Seignalet these criteria are too restrictive, in fact they do not exist yet in many disease states that are considered autoimmune diseases. Seignalet instead defines any autoimmune disease in which there is an immune response that can not be explained by the presence of microorganisms or whole tumors, and that involves injury or dysfunction of certain cells or tissues.
autoimmunity remains mysterious to most doctors, who consider it just a malfunction of the immune system, and use drugs that have only limited effects and partial, because they try to block the immune response and inflammation, but without resolving the underlying causes.
Seignalet says that the real autoimmune diseases, according to the classical definition, are rare and represent a small minority. In these cases, the change in food is helpless and the only use of the drugs remain.
The vast majority of these diseases, however, (including diabetes mellitus type I, rheumatoid arthritis, ankylosing spondylitis, lupus erythematosus, Graves-Basedow's disease, multiple sclerosis and celiac disease) may be defined xeno-immune: they correspond to a normal immune response that is followed by a normal inflammatory response, compared with healthy tissue initially, but an unwanted guest house consists of a peptide antigen came from outside .
This antigenic peptide comes from the small intestine and can be foodborne or bacteria. In a first period it accumulates without being recognized by the immune system (the phenomenon of immune tolerance), which at one point "wakes up" and triggers a reaction against the xeno-peptide, however going to also affect the cells that host . This would be a reaction direct immune, but there is also an indirect reaction (called cross-ownership) not going to hit the xenon-peptide, but a self-peptide that resembles, as well as the cell carriers of this self-peptide.
- diseases fouling (or impregnated): If some of the molecules from food and bacteria are immunogenic, ie they can provoke an immune response, some of them instead (such as polyamines and the famous Maillard molecules ) are not immunogenic, and therefore will be free to move around the body until they are attracted to certain cells or tissues , depending on their structure.
What is the fate of these molecules? Those of them whose structure differs significantly from the guest molecules will be partly swallowed by polynuclear neutrophils and macrophages, and some will accumulate in the extracellular matrix, degrade the performance.
Those of them, however, whose structure resembles the guest molecules will bind to the cell membrane (disturbing the functioning of receptors and ion channels) or leak into the cytoplasm and nucleus (disturbing the enzyme activity and non-enzymatic and the structure and regulation of genes).
The secondary consequences of this overload of toxic substances are the increase in energy consumption, the decrease in energy production, the disruption of the functioning of cells and the release of excessive free radicals.
What will be the final outcome? There are several possibilities: encrusted cells may die or run poorly (eg. Alzheimer's, Parkinson's, osteoporosis, diabetes type II), or may work incorrectly (eg. Hypercholesterolemia, l ' arthritis, gout, schizophrenia), or may experience pain (eg. fibromyalgia, spasmophilia, nervous depression endogenous) or they can become malignant (certain types of leukemia and certain types of cancer). Examples of other diseases fouling are: tendinitis, headaches, autism, obesity, atherosclerosis, sarcoidosis and premature aging.
- disease elimination : among the multitude of harmful molecules that enter the body through the lining of the small intestine only some are degradable by human enzymes. Many however are not, eg some of Maillard molecules (which are so tough to resist the bleach and detergent), nitrosamines, polycyclic aromatic hydrocarbons and heterocyclic amines (or carboline), produced by cooking above 110 ° C.
According Seignalet is clear that these molecules accumulate in tissues and cells and, according to him, those are the white blood cells normally responsible for elimination of these substances. Acting as the garbage collectors, they pick up through phagocytosis or endocytosis macromolecules carrying non-degradable and, after passing through a skin or mucous emunctory up outside the body. They are then expelled into the environment along with their "cargo".
performing their work, leukocytes emit cytokines that stimulate the proliferation of epithelial cells (exfoliation) and the secretion of the glandular cells (sputum, sebum ...).
What are these routes of elimination? The main streets are the liver through the bile, and the colon (or large intestine) through the feces. Other routes of elimination are the kidneys, small intestine, stomach, skin, bronchi, mucous membranes and conjunctiva of the eye sphere ORL.
pathological elimination appears to be eliminated when the molecules are abundant and activated leukocytes are numerous. The presence of a large amount of leukocytes in chronic inflammation causes emunctory. This inflammation is responsible, alone or in conjunction with other cofactors (bacteria, viruses, allergens, pollutants, foods, etc. ...), of diseases that vary dell'emuntorio in question, which depends on the structure of the molecule. The elimination biliary (bile diarrhea) is undoubtedly the least dangerous: the only drawback is a loss of minerals, especially phosphorus. In contrast, the crossing of the other excretory can have pathological consequences. At the level we can have digestive colitis, Crohn's disease, gastritis, duodenitis ... The skin can get acne, some types of eczema, psoriasis, hives ... A bronchial level we can have chronic bronchitis, asthma ... At the level of the mucous membranes of the head can be otitis, sinusitis, allergic rhinitis, chronic rhinitis, nasal polyps, the canker sores, Quincke's edema, conjunctivitis ...
For more information, I refer to the book by Jean Seignalet "L'alimentation ou la troisième médecine.
What do you think? What are the positive and negative?
Next time I'll talk about another alternative nosology is completely different from this.
(end of part one)
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